Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Pyrococcus furiosus | |
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Saccharolobus solfataricus | |
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Saccharolobus shibatae | |
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Methanocaldococcus jannaschii | |
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Archaeoglobus fulgidus | |
additional information | the archaeal Pol II-like transcription apparatus requires the general transcription factors TBP, TFB, TFE and TFS | Thermococcus kodakarensis | |
additional information | the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS | Saccharomyces cerevisiae | |
additional information | the Pol II transcription apparatus requires the transcription factors TBP, TFIIB, TFIIEalpha and TFIIS | Schizosaccharomyces pombe |
Crystallization (Comment) | Organism |
---|---|
crystal structure determination | Pyrococcus furiosus |
crystal structure determination | Saccharolobus shibatae |
crystal structure determination | Archaeoglobus fulgidus |
crystal structure determination, structure including the A' subunit jaw and clamp head domains and RpoG and Rpo13 subunits | Saccharolobus solfataricus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family | Homo sapiens | |
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family | Saccharomyces cerevisiae | |
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family | Schizosaccharomyces pombe | |
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif | Saccharolobus solfataricus | |
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family and contains one 4Fe-4S cluster binding motif | Saccharolobus shibatae | |
Iron | RNA polymerase is a member of the iron-sulfur cluster protein family and contains two 4Fe-4S cluster binding motifs | Archaeoglobus fulgidus | |
Mg2+ | the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit | Saccharolobus solfataricus | |
additional information | the Pyrococcus RNA polymerase does not contain iron-sulfur cluster binding motifs | Pyrococcus furiosus | |
additional information | the Thermococcus RNA polymerase does not contain iron-sulfur cluster binding motifs | Thermococcus kodakarensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Archaeoglobus fulgidus | - |
- |
- |
Homo sapiens | - |
- |
- |
Methanocaldococcus jannaschii | - |
- |
- |
Pyrococcus furiosus | - |
- |
- |
Saccharolobus shibatae | - |
- |
- |
Saccharolobus solfataricus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Schizosaccharomyces pombe | - |
- |
- |
Thermococcus kodakarensis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme active site is located on the back wall of the channel, where an essential Mg2+ ion is chelated by three Asp of the absolutely conserved NADFDGD motif in the A' subunit | Saccharolobus solfataricus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure analysis and modeling, overview | Saccharolobus shibatae |
More | structure analysis, overview, the enzyme contains a subunit Rpo13 located at a groove between the H subunit and the clamp head domain of the A' subunit, model ing including the A' subunit jaw and clamp head domains and RpoG and Rpo13, overview | Saccharolobus solfataricus |
More | the enzyme lacks the Rpb8 and Rpo13 subunits | Pyrococcus furiosus |
Synonyms | Comment | Organism |
---|---|---|
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Homo sapiens |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Saccharomyces cerevisiae |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Schizosaccharomyces pombe |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Saccharolobus solfataricus |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Saccharolobus shibatae |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Methanocaldococcus jannaschii |
More | RNA polymerase is a member of the iron-sulfur cluster protein family | Archaeoglobus fulgidus |
Pol II | - |
Saccharomyces cerevisiae |
Pol II | - |
Schizosaccharomyces pombe |
RNA polymerase | - |
Homo sapiens |
RNA polymerase | - |
Saccharomyces cerevisiae |
RNA polymerase | - |
Pyrococcus furiosus |
RNA polymerase | - |
Schizosaccharomyces pombe |
RNA polymerase | - |
Saccharolobus solfataricus |
RNA polymerase | - |
Saccharolobus shibatae |
RNA polymerase | - |
Methanocaldococcus jannaschii |
RNA polymerase | - |
Archaeoglobus fulgidus |
RNA polymerase | - |
Thermococcus kodakarensis |
RNAP | - |
Homo sapiens |
RNAP | - |
Saccharomyces cerevisiae |
RNAP | - |
Pyrococcus furiosus |
RNAP | - |
Schizosaccharomyces pombe |
RNAP | - |
Saccharolobus solfataricus |
RNAP | - |
Saccharolobus shibatae |
RNAP | - |
Methanocaldococcus jannaschii |
RNAP | - |
Archaeoglobus fulgidus |
RNAP | - |
Thermococcus kodakarensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Fe-S cluster | with 4Fe-4S cluster-binding motif | Saccharolobus solfataricus |